How Malaria Kills
Research on Malaria
Sunny spent more than a decade conducting research on malaria, taking an evolutionary approach to the disease in an effort to identify novel drug or vaccine targets. He discovered a new molecular “switch” that explains how malaria parasites escape human immune systems.
During his rotation in Dr. Kirk Deitsch's malaria laboratory—his final stop for the doctoral portion of his joint degree—he made a discovery that brings researchers one step closer to learning how malaria operates
Recruitment of PfSET2 by RNA Polymerase II to Variant Antigen Encoding Loci Contributes to Antigenic Variation in P. falciparum (PDF)
This work unifies previous reports of histone modifications, the production of ncRNAs, and the promoter activity of var introns into a mechanism that contributes to antigenic variation by malaria parasites
Horizontal Gene Transfer of Epigenetic Machinery and Evolution of Parasitism in the Malaria Parasite Plasmodium Falciparum and Other Apicomplexans (PDF)
Along with the horizontal transfer of cytoadhesive domains, O-linked glycosylation and key transcription factors, the acquisition of SET domain methyltransferases marks a key transitional event in the evolution to parasitism in this important protozoan lineage.